Syntaxin 1A regulates surface expression of β-cell ATP-sensitive potassium channels
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چکیده
منابع مشابه
Syntaxin 1A regulates surface expression of beta-cell ATP-sensitive potassium channels.
The pancreatic ATP-sensitive potassium (K(ATP)) channel consisting of four inwardly rectifying potassium channel 6.2 (Kir6.2) and four sulfonylurea receptor SUR1 subunits plays a key role in insulin secretion by linking glucose metabolism to membrane excitability. Syntaxin 1A (Syn-1A) is a plasma membrane protein important for membrane fusion during exocytosis of insulin granules. Here, we show...
متن کاملSyntaxin 1 A regulates surface expression of β - cell ATP - sensitive 1 potassium channels
26 The pancreatic ATP-sensitive potassium (KATP) channel consisting of four Kir6.2 and 27 four sulfonylurea receptor SUR1 subunits play a key role in insulin secretion by 28 linking glucose metabolism to membrane excitability. Syntaxin 1A is a plasma 29 membrane protein important for membrane fusion during exocytosis of insulin 30 granules. Here, we show that syntaxin 1A and KATP channels endog...
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Recent studies have shown that intracerebroventricular administration of cimetidine (CIM) induces anti-nociceptive and anti–inflammatory effects in rats. However, the underlying mechanism of CIM effect has not been determined yet. This study was planned to determine the anti-nociceptive effect of CIM (50 mg/kg, i.p.) in male mice (25-30 g, n = 80) using tail flick test. Also, the role of ATP-se...
متن کاملCardiovascular ATP-sensitive potassium channels
Sulfonylurea drugs stimulate endogenous insulin secretion by blockade of ATP-sensitive potassium channels in pancreatic beta cells. These drugs are widely used in the treatment of type 2 diabetes. However, as ATP-sensitive potassium channels also exist in cardiomyocytes and coronary and peripheral arterial vascular smooth muscle cells, sulfonylurea drug usage in theory may cause unwanted cardio...
متن کاملMCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning.
BACKGROUND MCC-134 (1-[4-(H-imidazol-1-yl)benzoyl]-N-methylcyclobutane-carbothioamide), a newly developed analog of aprikalim, opens surface smooth muscle-type ATP-sensitive potassium (K(ATP)) channels but inhibits pancreatic K(ATP) channels. However, the effects of MCC-134 on cardiac surface K(ATP) channels and mitochondrial K(ATP) (mitoK(ATP)) channels are unknown. A mixed agonist/blocker wit...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2011
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00429.2010